Associated Press reports that his death was confirmed by the health department official of Nuevo Leon state.
The cause of death has not been confirmed, but it is being speculated that he died from heart and liver problems.
He was hospitalized on May 2nd, due to abnormal heartbeat.
Since the summer of 2002, Meme has mostly been confined to his bed, due to inability to walk. The last time he left his home was in 2008 for his marriage.
He was 1, 230 pounds but slimmed down to 867 pounds. In an interview with ABC News, he said that lack of exercise contributed to his weight gain.